The American heavyweight was unable to exact revenge on the Gypsy King for his loss in their second bout, as Fury knocked Wilder down three times on his way to victory in their trilogy fight last weekend.
Wilder was immediately taken to a Nevada hospital to be checked over after the bruising encounter and he will now undergo surgery on a broken hand next week.
As a result of his injuries, the Nevada State Athletic Commission have suspended him until April 8, meaning he cannot return to the ring until that date unless he is medically cleared by a doctor beforehand.
It is unclear exactly when Wilder, known for his devastating right hand power, did the damage but he also has broken both a finger and knuckle.
Wilder is now expected to undergo surgery next week when he returns to his home state of Alabama.
His co-manager Shelly Finkel told The Sun: ‘Deontay broke his right hand behind the third knuckle and he has to have that fixed next week.
‘He has to have surgery, the knuckle is OK, it’s the bone behind the knuckle that broke. He’s sore but he was OK, he was home yesterday.
‘He’s healing and at this point, if everything is OK, after the hand surgery he’ll probably look to enter the ring mid next year, like April or May.’
Fury has also been handed a standard 45-day suspension following his victory, which was his first ever world heavyweight title defence.
Wilder has now suffered back-to-back defeats for the first time in his impressive career, after having previously not lost a single bout in 43 fights.
Fury’s win brought an end to their thrilling rivalry which started with their controversial draw in Los Angeles back in December 2018.
Their fight on Saturday was one of the best in recent years with Wilder knocking Fury down twice in the fourth round.
Fury floored the Alabama fighter in the third and 10th round, before referee Russell Mora intervened to stop the fight in the penultimate round.
Now their long-running trilogy has finally been concluded, all eyes are now focused on who each man will fight next.
The Gypsy King is next expected to fight mandatory challenger Dillian Whyte in 2022 – should the latter prevail in his fight with Otto Wallin on October 30 at the 02 Arena.
Despite failing to win in his last three fights, all against Fury, Wilder’s trainer Malik Scott has insisted the American has no plans to retire from the sport at this point.
Finkel even claimed that Wilder would be ‘interested’ in a fight with Anthony Joshua.
The British former world heavyweight champion is shaped up to face Oleksandr Usyk some point in early 2022 after activating his rematch clause following his defeat by the Ukrainian in London last month.
British fans will be desperate to see Joshua regain the WBA, WBO and IBF straps from Usyk in their rematch to set up an undisputed title fight with Fury in the future.
But, should he fail, a potential match-up with Wilder will be another highly-anticipated heavyweight bout every boxing fan will be pining to see.
Alongside a picture of the couple, she wrote on Instagram: ‘Deontay, to say I’m proud of you wouldn’t be justifiable for the heart and strength you shown in your performance.
‘A proven warrior through each and every round. You might not have gotten the belt but you gained respect and love of people around the world on an incredible historical fight.
‘You’re one hell of a man, a true warrior who God is continuing to prepare for greater heights to conquer & thrones to sit upon.
‘I know the weight of the crown can be heavy & trying, but God gives his HARDEST challenges to his strongets warriors & you’re nothing less than a King your ability to give it your all and never give up will never be questioned or gone unnoticed.
‘I love you more than I can ever express with words and the Lord knows our souls are forever connected in ways no one will ever understand.’