United and their ‘Noisy Neighbours” City are to square off outside their traditional grounds of Old Trafford and Etihad Stadium.
Both are going to Houston in the US to meet at the NRG Stadium in an invitational tournament, the International Champions Cup on July 20.
Both clubs made the announcement on Monday.
“The Manchester Derby is one of the world’s most iconic games,” City chief executive Ferran Soriano said in a club release.
“We are very excited to play it in front of our passionate American fans. There are so many great memories from this game in history and we can’t wait to create some new ones in Houston.”